[Frontiers in Bioscience 7, c83-96, August 1, 2002] 83 NOVEL TRENDS IN ORPHAN MARKET DRUG DISCOVERY: AMYOTROPHIC LATERAL SCLEROSIS AS A CASE STUDY
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چکیده
1. Summary 2. Overview 3. Background: General Lead Discovery Trends, 1990-Present 3.1. Overview 3.2. Drug Discovery for Huntington’s Disease 3.3. NIH Anticonvulsant Screening Program. 3.4. Aurora Biosciences and the Cystic Fibrosis Foundation 3.5. Best Practices 4. ALS: Clinical Characteristics and Experimental resources 4.1. Overview 4.2. Trends in ALS Basic Research 4.3. Clinical Development 4.4. Animal Models 4.5. Assays 5. Novel Lead Discovery Programs for ALS 5.1. Overview 5.2. ALS Treatment Initiative 5.3. John Hopkins Center for ALS Research 5.4. ALSA/Hereditary Disease Foundation Collaborative 5.5. ALS Therapy Development Foundation 6. Sources of recent drugs in clinical development 6.1. Overview 6.2. Traditional Lead Discovery 6.3. Theoretical Secondary Indications 6.4. Vitamins, Minerals, and Dietary Supplements 6.5. Clinical Observations 7. Conclusion
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